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Cholelithiasis is the formation of stones in the gallbladder. These stones accumulate over time and block the normal pathway of bile within the gallbladder. Upon blockage, bile stagnation occurs which causes salt precipitates and therefore increases the amount of stones in the gallbladder. You might be wondering what causes this stone formation. Specialists have found out that stone formation is related to obesity and other conditions such as diabetes and even hypothyroidism.